Tom Sheard reporting on doctoral research placement at the University of Auckland, New Zealand

In October 2018 I flew across the world to the laboratory of Dr David Crossman at the University of Auckland in New Zealand. The goal: to study pathological remodelling in human heart biopsies from patients with idiopathic dilated cardiomyopathy (IDCM), using the super-resolution imaging technique expansion microscopy (ExM). Our interest lies in seeing whether nanodomain … Continue reading Tom Sheard reporting on doctoral research placement at the University of Auckland, New Zealand

New review out now: Shining New Light on the Structural Determinants of Cardiac Couplon Function

Our new review article to mark 10 years since the first super-resolution imaging experiments on cardiac muscle:  Abstract: Remodelling of the membranes and protein clustering patterns during the pathogenesis of cardiomyopathies has renewed the interest in spatial visualisation of these structures in cardiomyocytes. Coincidental emergence of single molecule (super-resolution) imaging and tomographic electron microscopy tools in the … Continue reading New review out now: Shining New Light on the Structural Determinants of Cardiac Couplon Function

New review chapter: “Advances in the Visualization of Molecular Assemblies Within Cellular Signaling Nanodomains: Insights From a Decade of Mapping of Ryanodine Receptor Clusters”

Nanodomains are naturally assembled signaling stations, which facilitate fast and highly regulated signaling within and between cells. Calcium (Ca2+) nanodomains known as junctional membrane complexes (JMCs) transduce fast and highly synchronized intracellular signals, which are required by a variety of cell types. Common to most such nanodomains are clustered assemblies of the principal intracellular Ca2+ release channels, … Continue reading New review chapter: “Advances in the Visualization of Molecular Assemblies Within Cellular Signaling Nanodomains: Insights From a Decade of Mapping of Ryanodine Receptor Clusters”

Three Minute Thesis Competition held at The University of Leeds

Miriam recently entered the 'Three Minute Thesis' competition held at The University of Leeds. A video of the presentation has since been uploaded to the conference YouTube channel which you can access here. A particular highlight of this competition for Miriam was hearing fellow researchers from a variety of disciplines communicate the wide-ranging impact of … Continue reading Three Minute Thesis Competition held at The University of Leeds

Showcasing the recent and ongoing DNA-PAINT experiments at the Edinburgh Super Resolution Imaging Consortium Symposium

Isuru attended the second annual Edinburgh Super Resolution Imaging Consortium (ESRIC) symposium, held this year at the Institute of Genetics and Molecular Medicine (IGMM) of the University of Edinburgh (UoE). His talk on the Molecular-scale imaging of ryanodine receptors at both the cell surfaces and interiors with the adaptation of DNA-PAINT was well-received by a … Continue reading Showcasing the recent and ongoing DNA-PAINT experiments at the Edinburgh Super Resolution Imaging Consortium Symposium