We are starting to recruit PhD researchers for Oct 2021 start. Join a world-class, interdisciplinary and highly supportive research environment where you can learn about new cell biology projects and advanced microscopy techniques. Below, are the projects that are currently open to application. "Developing an ultra-fast and unbiased histopathology toolkit" We will develop a novel protocol … Continue reading New PhD studentships for October 2021 start
The protocols focuses on the principle of examining calcium sparks in living cells (main panel, left), and then aligning the image frames to the corresponding DNA-PAINT super-resolution images of the underlying clustering patterns of the Calcium release channels, the ryanodine receptors (magnified inset, right) Super-resolution microscopies are commonly utilised to obtain nanometre-scale information regarding the … Continue reading A new correlative super-resolution protocol to visualise cellular function and structure
Our latest pre-print is now online, where we evaluated two peptide ligands of the cardiac ryanodine receptor (RyR) as super-resolution imaging probes. The research was conducted in collaboration with one of our industrial partners, Badrilla Ltd., during the industrial internship of iCASE PhD student Tom Sheard funded through the DiMeN DTP. The peptides used were the scorpion … Continue reading Preprint outlining the utility of peptide ligands against RyR2 as potential super-resolution imaging probes
Our new book chapter has been published, detailing the enhanced expansion microscopy technique (EExM). The protocol offers a route to visualising cellular ultrastructures at a resolution of 15 nm in-plane (and ~ 35 nm axially) with a hydrogel-based molecular-scale imprint of the fluorescence pattern. We detail how we used EExM to explore structural and biochemical … Continue reading New book chapter detailing EExM in Methods in Cell Biology
We have launched a brief survey examining the needs in the Life Sciences around the use or potential utility of optical (fluorescence) microscopies. This takes ~ 6 minutes to complete and gives you an opportunity to stay in touch or engaged directly with the new developments of the newly launched UKRI Future Leader Fellowship within … Continue reading Optical microscopy bottlenecks survey
Applied Biophotonics Group 
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